No Priors with OpenAI President Greg Brockman: Cybersecurity, Drug Discovery, and the Math Results
39:23: Sarah Guo and Elad Gil talk with OpenAI president Greg Brockman about the math results, biology data bottlenecks, the always-on agent Dots, and the cybersecurity defender's window.
Key points Tap a time to jump
AI and mathematics: OpenAI's AI agents solved nearly 400 century-old math problems.
Drug discovery: Brockman named it a top AI application area, with biology's data bottlenecks needing new approaches.
Dots: OpenAI's proactive always-on agent tracks his to-dos, calendar conflicts, and work context across inbox and Slack.
Cybersecurity in the AI age: OpenAI moved about 25% of production engineers onto security, and turned its strongest model on its own infrastructure until it stopped finding new issues.
Shift in security investment: Brockman said cybersecurity spending should vastly outstrip software spending, as software gets cheaper and reliability and security become what buyers care about.
Human-centric ethos: humans should stay firmly in the driver's seat, and the technology should amplify human agency.
Comments
More to watch
All →- 1:34:05All-In Podcast E293: CoreWeave Crash, AI Trade Cracks, Anthropic IPO Red Flags, Bill Gates Doomer
- 1:49:56Why a 4-Billion-Point Kaggle Dataset Still Couldn't Beat Chance — Ian Quigley, Leash Bio (Latent Space)
- 28:04How to kill your SaaS: what we learned replacing a $43K/yr tool with AI agents
- 1:21:05Robots That Predict the Future: Dyna-2 & Physical AI — Jason Ma, Dyna Robotics
Latest news
All →- Oct 18Anthropic to Commit 5% of Shares to New Public Benefit Fund
- Oct 19Stably AI's Orca Tops GitHub Daily Trending: One Desktop App to Orchestrate 30+ Coding Agents
- Oct 19Jailbroken PS5 Becomes a Local AI Server: Qwen3.8-27B Hits ~20 tok/s, Small Models Top 100
- Oct 19Anthropic Internal Study: Junior Share of Technical Staff Falls to 14%, Meeting Time Up 20%
- Oct 18Claude Cracks 25-Year Cryptography Mystery in Half an Hour: NIST Curve Seeds Came From a 1997 Clock
- Oct 18OpenCode Hit by "Distillation Attack": API Keys of About 1.4% of Users Compromised
Today
Oct 19 Monday- Brief
- GitHubGitHub Weekly Vol.1: 8 Projects Worth Your Time
Tested or read — weeklyAll →
- Quiz
- Call
™